Dietary Supplement for Porphyria?
Ok - I know what porphyria is. I just wonder whether there is a dietary supplement that can help? Traditionally, culture with porphyria got the enzymes that their body lacked by drinking the organic blood of animals. Quite frankly, that's dangerous. There are expensive medications, both oral and injectible, that can be taken. But, I wonder, are there dietary supplements that could give support to? While a dietary cure is not at all likely, could there be something to lessen the amount of medication needed, thereby lowering the cost of watchfulness?
Best Answer: im sorry, but i dont know much about it and although you know what it is i found this interesting article. it wont help (im sorry) but i think you might want to read it anyways. correct luck! oh, and definately see your doctor and a nutritionist about this; they might have something for you but i dont know. The rare incurable disorder that made King George III suffer bouts of insanity may soon be treatable. The disease, which is particular as porphyria, afflicted a long line of monarchs in Europe. porphyria develops when the body produces excess amounts of molecules called porphyrins. Porphyrins are the building blocks for haem, the iron-rich component of haemoglobin. If the body fail to synthesise haem properly, porphyrins build up and can reach toxic levels. Patients with this disorder can suffer from a widespread range of symptoms including port-coloured faeces, stomach pains, muscle weakness and hypersensitivity to light. The chemicals can also interfere near the nervous system, causing mental illness. John Rshl, a historian at Sussex University, say convincing evidence has recently come to light that Mary Queen of Scots suffered from a inherent form of the disease, called variegate porphyria. This was passed down to George III, England's "mad" king. The disorder continued through his son George IV and Queen Victoria to the last confirmed sufferer, Elizabeth II's first cousin Prince William of Gloucester, who died contained by a plane crash in 1972. Germany's last kaiser, Wilhelm II, and the last Russian empress, Tsarina Alexandra-who be related to the British royal family-may also have had the disease. Variegate porphyria is caused by a genetic mutation that affects the success of an enzyme called protoporphyrinogen oxidase found in the mitochondria of cells. When this enzyme fail to work properly, excess protoporphyrinogen spills out into the surrounding cell. Scientists aren't clear what happens next, but they think that oxygen oxidises the protoporphyrinogen molecules, forming massive amounts of the porphyrin "protoporphyrin" in an uncontrolled reaction. Now a team of researchers lead by Nick Jacobs at Dartmouth Medical School in New Hampshire and Franck Dayan at the US Department of Agriculture's Natural Products Utilization Research Unit in Mississippi have discovered fluently occurring enzymes can detoxify these porphyrins. They can only do this with help from two substances contained by the body-glutathione, an antioxidant peptide, and the amino acid cysteine. The team showed that an enzyme from cows called lactoperoxidase could use glutathione or cysteine to convert protoporphyrin into a more water-soluble porphyrin surrounded by a test tube. "This would, in theory, greatly develop the ability of the body to eliminate protoporphyrin, either contained by the urine or in the faeces," says Dayan. The results will be reported in a adjectives issue of Biochemical and Biophysical Research Communications. Enzymes that could do the same job exist in humans, the researchers believe, raise the possibility that patients could take glutathione or cysteine supplements to fight porphyria. "The stage is set for other researchers to feed society glutathione," says Dayan. If a treatment for the disease had been available centuries ago, it may economically have changed the course of history. "Because of his illness, George III did not do things he might have. He intended to rule Parliament and establish a strong monarchy," say Rshl. "Instead, the power of Parliament took rapid strides during his reign."
http://news.bio-medicine.org/biology-news-2/Dietary-Supplements-Could-Put-A-Stop-To-A-Royal-Curse-13100-1/
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Best Answer: im sorry, but i dont know much about it and although you know what it is i found this interesting article. it wont help (im sorry) but i think you might want to read it anyways. correct luck! oh, and definately see your doctor and a nutritionist about this; they might have something for you but i dont know. The rare incurable disorder that made King George III suffer bouts of insanity may soon be treatable. The disease, which is particular as porphyria, afflicted a long line of monarchs in Europe. porphyria develops when the body produces excess amounts of molecules called porphyrins. Porphyrins are the building blocks for haem, the iron-rich component of haemoglobin. If the body fail to synthesise haem properly, porphyrins build up and can reach toxic levels. Patients with this disorder can suffer from a widespread range of symptoms including port-coloured faeces, stomach pains, muscle weakness and hypersensitivity to light. The chemicals can also interfere near the nervous system, causing mental illness. John Rshl, a historian at Sussex University, say convincing evidence has recently come to light that Mary Queen of Scots suffered from a inherent form of the disease, called variegate porphyria. This was passed down to George III, England's "mad" king. The disorder continued through his son George IV and Queen Victoria to the last confirmed sufferer, Elizabeth II's first cousin Prince William of Gloucester, who died contained by a plane crash in 1972. Germany's last kaiser, Wilhelm II, and the last Russian empress, Tsarina Alexandra-who be related to the British royal family-may also have had the disease. Variegate porphyria is caused by a genetic mutation that affects the success of an enzyme called protoporphyrinogen oxidase found in the mitochondria of cells. When this enzyme fail to work properly, excess protoporphyrinogen spills out into the surrounding cell. Scientists aren't clear what happens next, but they think that oxygen oxidises the protoporphyrinogen molecules, forming massive amounts of the porphyrin "protoporphyrin" in an uncontrolled reaction. Now a team of researchers lead by Nick Jacobs at Dartmouth Medical School in New Hampshire and Franck Dayan at the US Department of Agriculture's Natural Products Utilization Research Unit in Mississippi have discovered fluently occurring enzymes can detoxify these porphyrins. They can only do this with help from two substances contained by the body-glutathione, an antioxidant peptide, and the amino acid cysteine. The team showed that an enzyme from cows called lactoperoxidase could use glutathione or cysteine to convert protoporphyrin into a more water-soluble porphyrin surrounded by a test tube. "This would, in theory, greatly develop the ability of the body to eliminate protoporphyrin, either contained by the urine or in the faeces," says Dayan. The results will be reported in a adjectives issue of Biochemical and Biophysical Research Communications. Enzymes that could do the same job exist in humans, the researchers believe, raise the possibility that patients could take glutathione or cysteine supplements to fight porphyria. "The stage is set for other researchers to feed society glutathione," says Dayan. If a treatment for the disease had been available centuries ago, it may economically have changed the course of history. "Because of his illness, George III did not do things he might have. He intended to rule Parliament and establish a strong monarchy," say Rshl. "Instead, the power of Parliament took rapid strides during his reign."
http://news.bio-medicine.org/biology-news-2/Dietary-Supplements-Could-Put-A-Stop-To-A-Royal-Curse-13100-1/
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